Effects of Sacubitril valsartan sodium combined with conventional medication in treatment of patients with chronic heart failure complicated with hypertension
Objective:To observe effects of Sacubitril valsartan sodium combined with conventional medication in treatment of patients with chronic heart failure complicated with hypertension.Methods:A prospective study was conducted on 106 patients with chronic heart failure and hypertension admitted to the hospital from March 2017 to September 2022.According to the random number table method,they were divided into study group and control group,53 cases in each group.The control group was treated with conventional medication,while the study group was treated with Sacubitril valsartan sodium tablets on the basis of that of the control group.The total effective rate,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)]levels,the serum myocardial injury markers[creatine kinase isoenzyme(CK-MB),troponin,brain natriuretic peptide]levels,the C-reactive protein(CRP)level,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.23%,which was significantly higher than 84.91%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the LVEF levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of LVESD,LVEDD,CK-MB,troponin,brain natriuretic peptide and CRP in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Sacubitril valsartan sodium combined with conventional medication in the treatment of the patients with chronic heart failure and hypertension can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of myocardial injury markers and CRP.Moreover,it is superior to single conventional medication treatment.
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