Effects of Epalrestat combined with conventional drugs in treatment of patients with diabetic nephropathy
Objective:To observe effects of Epalrestat combined with conventional drugs in treatment of patients with diabetic nephropathy.Methods:A prospective study was conducted on 116 patients with diabetic nephropathy admitted to this hospital from January 2021 to January 2023.According to the random number table method,they were divided into study group and control group,58 cases in each group.Both groups received basic treatment.On this basis,the control group was treated with conventional drug(Pioglitazone+Alprostadil),while the study group was treated with Epalrestat on the basis of that of the control group.Both groups were treated for 3 months.The clinical efficacy,the renal function indexes[serum creatinine(Scr),24h urinary protein quantification(24h UP),blood urea nitrogen(BUN)]levels,the inflammatory indexes[C-reactive protein(CRP),interleukin-6(IL-6)]levels and the oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 89.66%(52/58),which was higher than 75.86%(44/58)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Scr,BUN and 24h UP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of SOD in the study group was higher than that in the control group,the level of MDA was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Epalrestat combined with conventional drugs in the treatment of the patients with diabetic nephropathy can improve the total effective rate of treatment,reduce the levels of renal function indexes and inflammatory indexes,and improve the levels of oxidative stress indexes.Moreover,it is superior to single conventional drug treatment.
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