Effects of Ranibizumab combined with laser in treatment of macular edema secondary to retinal vein occlusion
Objective:To observe effects of Ranibizumab combined with laser in treatment of macular edema secondary to retinal vein occlusion(RVO).Methods:The clinical data of 78 patients with macular edema secondary to RVO admitted to this hospital from July 2021 to March 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,39 cases in each group.The control group was treated with retinal laser photocoagulation,while the study group was treated with intravitreal injection of Ranibizumab before the laser surgery.The clinical efficacy,the best corrected visual acuity(BCVA),the central macular thickness(CMT),the aqueous humor inflammatory factors[interleukin-8(IL-8),monocyte chemoattractant protein-1(MCP-1),stromal cell derived factor-1(SDF-1)]levels,the vascular endothelial growth factor(VEGF)levels,and the incidence of complications were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 92.31%(36/39),which was higher than 74.36%(29/39)of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the BCVA and CMT values of the study group were lower than those of the control group,the levels of IL-8,MCP-1,SDF-1 and VEGF in aqueous humor were lower than those of the control group,and the differences were statistically significant(P<0.05).Further,the incidence of complications in the study group was 5.13%(2/39),which was lower than 23.08%(9/39)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Ranibizumab combined with laser is effective in the treatment of macular edema secondary to RVO.It can reduce the macular edema,promote the visual recovery,and reduce the levels of inflammatory factors and VEGF in aqueous humor and the incidence of complications.Moreover,it is superior to single laser treatment.
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