Effects of Compound glycyrrhizin tablets combined with Cyclosporine in treatment of generalized pustular psoriasis
Objective:To observe effects of Compound glycyrrhizin tablets combined with Cyclosporine in treatment of generalized pustular psoriasis.Methods:A prospective study was conducted on 73 patients with generalized pustular psoriasis admitted to the hospital from October 2017 to March 2023.According to the random number table method,they were divided into control group(n=37)and observation group(n=36).The control group was treated with Cyclosporine soft capsules,while the observation group was treated with Compound glycyrrhizin tablets on the basis of that of the control group.The clinical effects,the symptom relief time,the severity of disease[psoriasis area and severity index(PASI)]score,the quality of life[dermatology life quality index(DLQI)]score,the inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)]levels,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 94.44%(34/36),which was higher than 72.97%(27/37)of the control group,and the difference was statistically significant(P<0.05).The erythema relief time,the body temperature recovery time and the pustule relief time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PASI and DLQI scores of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,PCT and CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was 13.89%(5/36),which was lower than 35.14%(13/37)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Compound glycyrrhizin tablets combined with Cyclosporine in the treatment of the patients with generalized pustular psoriasis can improve the total effective rate of treatment,shorten the symptom relief time and reduce the PASI scores,the DLQI scores,the inflammatory factor levels and the recurrence rate.Moreover,it is superior to single Cyclosporine treatment.
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