Application effects of Dexmedetomidine combined with Ropivacaine for patient-controlled epidural analgesia in primipara delivery
Objective:To observe application effects of Dexmedetomidine combined with Ropivacaine for patient-controlled epidural analgesia in primipara delivery.Methods:A prospective study was conducted on 188 primiparas who gave birth in the hospital from January 2022 to June 2023.According to the random number table method,they were divided into control group and observation group,94 cases in each group.The control group was given Ropivacaine for analgesia,while the observation group was given Dexmedetomidine for analgesia on the basis of that of the control group.The hemodynamic index levels[heart rate,systolic blood pressure and mean arterial pressure(MAP)]at different time[before analgesia(T0),10 min after analgesia(T1),30 min after analgesia(T2),and immediate delivery of the fetus(T3)],the visual analogue scale(VAS)scores at different time(before analgesia,20 min after analgesia,immediate delivery of fetus),the oxidative stress index[superoxide dismutase(SOD),homocysteine(Hcy)]levels,and the incidence of adverse reactions were compared between the two groups.Results:At T1 and T3,the heart rate,systolic blood pressure and MAP levels of the two groups were lower than those at T0,but those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).At T2,the heart rate levels of both groups were lower than at those at T0,but there was no statistically significant difference between the two groups(P>0.05).The systolic blood pressure and MAP levels of the two groups were lower than those at T0,but those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).20 min after analgesia and when the cervix was fully opened,the VAS scores of the two groups were lower than those before analgesia,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).1 day after delivery,the SOD level of the two groups was lower than that those before delivery,but that in the observation group was higher than that in the control group;the Hcy levels of the two groups were higher than those before delivery,but that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 2.13%(2/94),which was lower than 9.57%(9/94)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Dexmedetomidine combined with Ropivacaine for patient-controlled epidural analgesia in the primipara delivery can stabilize the levels of hemodynamic indexes,reduce the labor pain,reduce the body's oxidative stress response,and reduce the incidence of adverse reactions.Moreover,it is superior to simple patient-controlled epidural Ropivacaine analgesia.
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