Effects of Methylprednisolone combined with GnRHa in treatment of patients with endometriosis complicated with recurrent early spontaneous abortion
Objective:To observe effects of Methylprednisolone combined with Gonadotropin-releasing hormone agonist(GnRHa)in treatment of patients with endometriosis complicated with recurrent early spontaneous abortion.Methods:A prospective study was conducted on 150 patients with endometriosis complicated with recurrent early spontaneous abortion admitted to the hospital from April 2022 to January 2023.They were divided into control group and study group by using the random number table method,75 cases in each group.The control group was treated with GnRHa,while the study group was treated with Methylprednisolone on the basis of that of the control group.The clinical treatment effect,the abdominal pain degree[numerical rating scale(NRS)]score,the sex hormone(progesterone,luteinizing hormone,follicle stimulating hormone,estradiol)levels before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the study group was 97.33%(73/75),which was higher than 88.00%(66/75)of the control group,and the difference was statistically significant(P<0.05).After 1,3 and 6 months of treatment,the NRS scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of progesterone,luteinizing hormone,follicle stimulating hormone and estradiol in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Methylprednisolone combined with GnRHa in the treatment of endometriosis with recurrent early spontaneous abortion can improve the total effective rate of treatment and reduce the NRS scores and the sex hormone levels.Moreover,it is superior to single GnRHa treatment.
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