Effects of Dipyridamole combined with Immunoglobulin and Aspirin in treatment of children with Kawasaki disease
Objective:To observe effects of Dipyridamole combined with Immunoglobulin and Aspirin in treatment of children with Kawasaki disease.Methods:A prospective study was conducted on 80 children with Kawasaki disease admitted to the hospital from June 2018 to June 2023.They were divided into control group(n=40)and observation group(n=40)by using the random number table method.The control group was treated with intravenous injection of Immunoglobulin combined with Aspirin,while the observation group was treated with Dipyridamole tablets on the basis of that of the control group.The disappearance time of clinical symptoms(fever,conjunctival congestion,chapped lips,rash,non-suppurative enlargement of cervical lymph nodes,and hard swelling of hands and feet),the hospitalization time,the levels of inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP)]and T cell subsets before and after the treatment,the incidence of coronary artery injury(CAL),and the incidence of adverse reactions during treatment were compared between the two groups.Results:The disappearance time of clinical symptoms such as fever,conjunctival congestion,chapped lips,rash,non-suppurative enlargement of cervical lymph nodes,and hard swelling of hands and feet and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,PCT and hs-CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD4+and CD4+/CD8+in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of CD8+in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).The incidence of CAL in the observation group was 7.50%,which was lower than 32.50%in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dipyridamole combined with Immunoglobulin and Aspirin in the treatment of the children with Kawasaki disease can shorten the disappearance time of clinical symptoms and the hospitalization time,improve the levels of T cell subsets,and reduce the levels of inflammatory factors and the incidence of CAL.Moreover,it is superior to Immunoglobulin combined with Aspirin treatment.
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