Effects of different doses of Levosimendan combined with Shexiang Baoxin pills in treatment of patients with acute myocardial infarction complicated with heart failure
Objective:To observe effects of different doses of Levosimendan combined with Shexiang Baoxin pills in treatment of patients with acute myocardial infarction complicated with heart failure.Methods:A prospective study was conducted on 62 patients with acute myocardial infarction complicated with heart failure admitted to the hospital from December 2022 to December 2023.According to the random number table method,they were divided into control group and observation group,31 cases in each group.Both groups were treated with routine treatment+Shexiang Baoxin pills.On this basis,the control group was treated with low-dose Levosimendan,while the observation group was treated with high-dose Levosimendan.Both groups were treated for 1 month.The clinical efficacy,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)]levels,the myocardial injury markers[N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB)]levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.55%(29/31),which was higher than 67.74%(21/31)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of LVEF in the observation group was higher than that in the control group,the levels of LVEDV and LVESV were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NT-proBNP,CK-MB and cTnI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:High-dose Levosimendan combined with Shexiang Baoxin pills in the treatment of the patients with acute myocardial infarction complicated with heart failure can improve the total effective rate of treatment,improve the levels of cardiac function indexes,and reduce the levels of myocardial injury markers and inflammatory factors.Moreover,it is superior to small dose of Levosimendan combined with Shexiang Baoxin pills treatment.
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NSTL
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