Effects of Chitong Xiaoyanling granules combined with Metronidazole on inflammation and pain after root canal therapy in patients with chronic apical periodontitis
Objective:To investigate effects of Chitong Xiaoyanling granules combined with Metronidazole on inflammation and pain after root canal therapy in patients with chronic apical periodontitis.Methods:A total of 95 patients with chronic apical periodontitis who underwent root canal treatment in this hospital from October 2021 to October 2023 were selected.According to the random number table method,they were divided into control group(n=47)and observation group(n=48).On the basis of the root canal treatment,the control group was treated with Metronidazole tablets,while the observation group was treated with Chitong Xiaoyanling granules on the basis of that of the control group.The clinical efficacy,the periodontal indexes[gingival index(GI),plaque index(PLI)]levels,the gingival crevicular fluid inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)]levels,visual analogue scale(VAS)score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.67%(44/48),which was higher than 76.60%(36/47)of the control group,and the difference was statistically significant(P<0.05).After 7 days of treatment,the scores of GI,PLI,VAS and the levels of TNF-α,IL-1β and IL-6 in gingival crevicular fluid in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Chitong Xiaoyanling granules combined with Metronidazole can improve the clinical efficacy,improve the periodontal index levels,reduce the levels of inflammatory factors in the gingival crevicular fluid and relieve the tooth pain in the patients with chronic apical periodontitis after root canal treatment.Moreover,it is superior to single Metronidazole treatment.
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