Efficiency of combined application of serum HMGB1,IL-17 levels and qSOFA score in prognosis evaluation of patients with severe respiratory failure
Objective:To analyze efficiency of serum high mobility group protein B1(HMGB1),interleukin-17(IL-17)levels and quick sequential organ failure(qSOFA)score in prognosis evaluation of patients with severe respiratory failure.Methods:A cross-sectional study was conducted on 124 patients with severe respiratory failure admitted to this hospital from May 2021 to May 2023.According to the 28-day survival situations after admission,they were divided into survival group(n=87)and death group(n=37).The serum HMGB1 and IL-17 levels were measured and the qSOFA scores were evaluated in all patients 12 hours after admission.The receiver operating characteristic(ROC)curve was used to analyze the efficiency of single and combine application of serum HMGB1,IL-17 levels and qSOFA score the in the prognosis evaluation of patients with severe respiratory failure.Results:The serum HMGB1 and IL-17 levels and the qSOFA scores in the survival group were lower than those in the death group,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combine application of serum HMGB1 level,IL-17 level and qSOFA score in the prognosis evaluation of the patients with severe respiratory failure were 0.869,0.832,0.784 and 0.957,respectively,which had certain predictive value,and the evaluation efficiency of combined application was higher than that of single application.Conclusions:The efficiency of combined application of serum HMGB1 level,IL-17 level and qSOFA score in the prognosis evaluation of the patients with severe respiratory failure is higher than that of single application of the three.
High mobility group protein B1Interleukin-17Quick sequential organ failure scoreSevereRespiratory failurePrognosis
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