Correlations among HBV-DNA load and serum marker levels in patients with hepatitis B and its predictive value for antiviral efficacy
Objective:To observe correlations among HBV-DNA load and serum marker[hepatitis B surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg),hepatitis B virus core antibody(HBcAb),HBcAb-immunoglobulin(IgM)]levels in patients with hepatitis B and its predictive value for antiviral efficacy.Methods:A prospective study was conducted on 154 patients with hepatitis B admitted to the hospital from July 2020 to July 2022.The levels of HBV-DNA load and serum markers were measured on admission and 1 month after antiviral treatment.Pearson correlation analysis was used to analyze the correlations among the HBV-DNA load on admission and the serum markers levels in the hepatitis B patients.The levels of HBV-DNA load and serum markers were compared between 6 months of antiviral treatment and 1 month of antiviral treatment.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of single and combined detection of HBV-DNA load and serum markers levels at 1 month after antiviral treatment for 6 months after antiviral treatment.Results:Pearson correlation analysis showed that the HBV-DNA load was positively correlated with the serum HBsAg,HBeAg,HBcAb and HBcAb-IgM levels in the patients with hepatitis B at admission(r>0,P<0.05).The HBV-DNA load and the serum HBsAg,HBeAg,HBcAb and HBcAb-IgM levels in the patients with complete response after 6 months of antiviral treatment were lower than those in the patients with incomplete response at 1 month of treatment,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the predictive value of combined detection of HBV-DNA load and serum HBsAg,HBeAg,HBcAb and HBcAb-IgM levels after 1 month of antiviral treatment in the patients with hepatitis B for 6 months of antiviral treatment[area under the curve(AUC)=0.905]was higher than the predictive value of single detection of the five(AUC=0.779,0.802,0.792,0.739,0.831).Conclusions:The HBV-DNA load in the patients with hepatitis B is positively correlated with the serum HBsAg,HBeAg,HBcAb and HBcAb-IgM levels.Further,the predictive value of combined detection of HBV-DNA load and serum HBsAg,HBeAg,HBcAb and HBcAb-IgM levels in the patients with hepatitis B after 1 month of antiviral treatment was higher than that of single detection of the five for 6 months of antiviral treatment.
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