Effects of Esmolol combined with Amiodarone in treatment of patients with coronary heart disease complicated with arrhythmia
Objective:To observe effects of Esmolol combined with Amiodarone in treatment of patients with coronary heart disease complicated with arrhythmia.Methods:A prospective study was conducted on 80 patients with coronary heart disease complicated with arrhythmia admitted to the hospital from August 2021 to December 2022.According to the random number table method,they were divided into observation group and control group,40 cases in each group.The control group was treated with Amiodarone,while the observation group was treated with Esmolol on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),cardiac output(CO),left ventricular short axis shortening rate(FS)],the disease-related indexes(QTc interval,ventricular premature contraction,short array ventricular tachycardia)levels,the myocardial injury marker indexes[troponin I(cTnI),creatine kinase isoenzyme(CK-MB)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 90.00%(36/40),which was higher than 70.00%(28/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF,CO and FS in the two groups were higher than those before the treatment,and those in the observation group were higher than the those in the control group;the LVESD levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the QTc interval of the two groups was longer than that before the treatment,and that in the observation group was longer than that in the control group;the ventricular premature contraction and the short ventricular tachycardia in the two groups were less than those before the treatment,and those in the observation group were less than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of cTnI and CK-MB in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Esmolol combined with Amiodarone in the treatment of the patients with coronary heart disease complicated with arrhythmia can improve the total effective rate of treatment,improve the levels of disease-related indexes and cardiac function indexes,and reduce the levels of myocardial injury markers.Moreover,it is superior to single Amiodarone treatment.
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