Effects of Salbutamol combined with noninvasive mechanical ventilation in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease
Objective:To observe effects of Salbutamol combined with noninvasive mechanical ventilation in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The clinical data of 92 patients with AECOPD admitted to this hospital from January 2022 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,46 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with noninvasive mechanical ventilation,while the study group was treated with Salbutamol on the basis of that of the control group.The clinical efficacy,the levels of lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],oxygen metabolism indexes[arterial partial pressure of oxygen(PaO2),blood lactic acid(Lac),oxygen consumption index(DO2),oxygen uptake rate(O2ER)]and inflammatory indexes[interleukin(IL)-13,IL-17,IL-35,soluble myeloid cell trigger receptor-1(sTREM-1)],and the incidence of adverse reactions or complications were compared between the two groups.Results:The total effective rate of the study group was 93.48%(43/46),which was higher than 78.26%(36/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and FEV1/FVC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PaO2,O2ER and DO2 in the study group were higher than those in the control group,the level of Lac was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-13,IL-17 and sTREM-1 in the study group were lower than those in the control group,the level of IL-35 was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions or complications between the two groups(P>0.05).Conclusions:Salbutamol combined with noninvasive mechanical ventilation in the treatment of the AECOPD patients can increase the total effective rate and the lung function index levels,improve the oxygen metabolism index and inflammatory index levels.Moreover,it is superior to single noninvasive mechanical ventilation treatment.
Acute exacerbation of chronic obstructive pulmonary diseaseSalbutamolNoninvasive mechanical ventilationOxygen metabolismLung function
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