Effects of Terbutaline combined with Montelukast sodium in treatment of patients with bronchial asthma
Objective:To observe effects of Terbutaline combined with Montelukast sodium in treatment of patients with bronchial asthma.Methods:A prospective study was conducted on 186 patients with bronchial asthma admitted to the hospital from January 2020 to December 2022.They were divided into control group(n=93)and study group(n=93)by using the random number table method.The control group was treated with Montelukast sodium,while the study group was treated with Terbutaline on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),interleukin-17(IL-17)],oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD)]and respiratory mechanics indexes[peak airway pressure(PIP),airway resistance(Raw),respiratory work(WOB)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.62%(88/93),which was higher than 81.72%(76/93)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-8 and IL-17 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of MDA in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the levels of SOD in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The levels of PIP,Raw and WOB in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Terbutaline combined with Montelukast sodium in the treatment of the patients with bronchial asthma can improve the total effective rate of treatment,improve the levels of oxidative stress indexes and reduce the levels of respiratory mechanics indexes and inflammatory factors.Moreover,it is superior to single Montelukast sodium treatment.
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