首页|经脐单孔加一腹腔镜结直肠癌根治术治疗结直肠癌患者的效果

经脐单孔加一腹腔镜结直肠癌根治术治疗结直肠癌患者的效果

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目的:观察经脐单孔加一(SILS+1)腹腔镜结直肠癌根治术治疗结直肠癌患者的效果.方法:回顾性分析 2020 年 1 月至2023 年 5 月信阳市传染病医院收治的 84 例结直肠癌患者的临床资料,按手术方案不同将其分为研究组和对照组各 42 例.两组均行腹腔镜结直肠癌根治术,研究组应用SILS+1治疗,对照组采用5孔法治疗,比较两组围术期指标水平、手术前后肿瘤标志物[癌胚抗原(CEA)、糖类抗原 125(CA125)、糖类抗原 19-9(CA19-9)]水平、疼痛程度[视觉模拟评分法(VAS)]评分、炎性因子[γ干扰素(IFN-γ)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平和随访 1 个月的并发症发生率.结果:两组术中失血量比较,差异无统计学意义(P>0.05);研究组首次排气时间、住院时间均短于对照组,手术时间长于对照组,差异有统计学意义(P<0.05);术后1个月,两组血清CEA、CA125、CA19-9 水平均低于术前,但组间比较,差异无统计学意义(P>0.05);术后 1、3 d,两组VAS评分均高于术前,但研究组低于对照组,差异有统计学意义(P<0.05);术后1 d,两组血清IFN-γ、IL-1β、TNF-α水平均高于术前,但研究组低于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05).结论:经脐SILS+1 腹腔镜结直肠癌根治术治疗结直肠癌患者可缩短首次排气时间和住院时间,降低炎性因子水平和疼痛程度评分,效果优于 5 孔法治疗,但会延长手术时间.
Effects of transumbilical single-port plus one port laparoscopic radical resection of colorectal cancer in treatment of patients with colorectal cancer
Objective:To observe effects of transumbilical single-port plus one port(SILS+1)laparoscopic radical resection of colorectal cancer in patients with colorectal cancer.Methods:The clinical data of 84 patients with colorectal cancer admitted to Xinyang Infectious Disease Hospital from January 2020 to May 2023 were retrospectively analyzed.According to different surgical schemes,they were divided into study group and control group,42 cases in each group.Both groups underwent laparoscopic radical resection of colorectal cancer.The study group was treated with SILS+1,while the control group was treated with 5-port method.The perioperative index levels and the tumor marker indexes[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9)]levels,the pain degree[visual analogue scale(VAS)]score,the inflammatory factors[γ-interferon(IFN-γ),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]levels before and after the surgery,and the incidence of complications after 1 month of follow-up were compared between the two groups before and after the surgery.Results:There was no significant difference in the intraoperative blood loss between the two groups(P>0.05).The first exhaust time and the hospitalization time of the study group were shorter than those of the control group,the operation time was longer than that of the control group,and the differences were statistically significant(P<0.05).1 month after the surgery,the average levels of CEA,CA125 and CA19-9 in the two groups were lower than before the surgery,but there were no statistically significant differences between the groups(P>0.05).1 and 3 days after the surgery,the VAS scores of the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).1 day after the surgery,the levels of serum IFN-γ,IL-1β and TNF-α in the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Transumbilical SILS+1 laparoscopic radical resection of colorectal cancer can shorten the first exhaust time and the hospitalization time,and reduce the levels of inflammatory factors and the pain scores in the patients with colorectal cancer.Moreover,it is superior to 5-hole method,but it will prolong the operation time.

Transumbilical single-port plus one portColorectal cancerLaparoscopyTumor markerInflammatory factorComplicationPain degree

谭海、王卓

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信阳市第五人民医院 信阳市传染病医院外科,河南 信阳 464100

经脐单孔加一 结直肠癌 腹腔镜 肿瘤标志物 炎性因子 并发症 疼痛程度

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(11)
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