Effects of transumbilical single-port plus one port laparoscopic radical resection of colorectal cancer in treatment of patients with colorectal cancer
Objective:To observe effects of transumbilical single-port plus one port(SILS+1)laparoscopic radical resection of colorectal cancer in patients with colorectal cancer.Methods:The clinical data of 84 patients with colorectal cancer admitted to Xinyang Infectious Disease Hospital from January 2020 to May 2023 were retrospectively analyzed.According to different surgical schemes,they were divided into study group and control group,42 cases in each group.Both groups underwent laparoscopic radical resection of colorectal cancer.The study group was treated with SILS+1,while the control group was treated with 5-port method.The perioperative index levels and the tumor marker indexes[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9)]levels,the pain degree[visual analogue scale(VAS)]score,the inflammatory factors[γ-interferon(IFN-γ),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]levels before and after the surgery,and the incidence of complications after 1 month of follow-up were compared between the two groups before and after the surgery.Results:There was no significant difference in the intraoperative blood loss between the two groups(P>0.05).The first exhaust time and the hospitalization time of the study group were shorter than those of the control group,the operation time was longer than that of the control group,and the differences were statistically significant(P<0.05).1 month after the surgery,the average levels of CEA,CA125 and CA19-9 in the two groups were lower than before the surgery,but there were no statistically significant differences between the groups(P>0.05).1 and 3 days after the surgery,the VAS scores of the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).1 day after the surgery,the levels of serum IFN-γ,IL-1β and TNF-α in the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Transumbilical SILS+1 laparoscopic radical resection of colorectal cancer can shorten the first exhaust time and the hospitalization time,and reduce the levels of inflammatory factors and the pain scores in the patients with colorectal cancer.Moreover,it is superior to 5-hole method,but it will prolong the operation time.
Transumbilical single-port plus one portColorectal cancerLaparoscopyTumor markerInflammatory factorComplicationPain degree