Effects of Goserelin combined with Estradiol valerate in treatment of postoperative patients with endometriosis
Objective:To observe effect of Goserelin combined with Estradiol valerate in the treatment of postoperative patients with endometriosis(EMT).Methods:A prospective study was conducted on 60 patients with EMT admitted to the hospital from April 2021 to April 2022.According to the random number table method,they were divided into control group and study group,30 cases in each group.The control group was treated with Estradiol valerate,while the study group was treated with Goserelin on the basis of that of the control group.The clinical efficacy,the dysmenorrhea degree[visual analogue scale(VAS)]and menstrual volume[pictorial blood loss assessment chart,(PBAC)]scores,the levels of sex hormone indexes[luteinizing hormone(LH),follicle stimulating hormone(FSH),Estradiol(E2)]and serological indexes[vascular endothelial growth factor(VEGF),soluble intercellular adhesion molecule-1(sICAM-1)],the incidence of adverse reactions,and the 1-year recurrence rate were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 93.33%(28/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the VAS and PBAC scores of the two groups were lower than those before the treatment,those of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The levels of LH,FSH and E2 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of VEGF and sICAM-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 1 year of follow-up,2 cases were lost in the study group and 5 cases in the control group.The recurrence rate of the study group was 3.57%(1/28),which was lower than 32.00%(8/25)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Goserelin combined with Estradiol valerate in the treatment of the postoperative patients with EMT can improve the clinical efficacy,reduce the degree of dysmenorrhea and the menstrual blood loss,improve the levels of sex hormones,and reduce the levels of VEGF,sICAM-1 and the recurrence rate.Moreover,it is superior to single Estradiol valerate treatment.