首页|一次性宫腔压迫球囊联合卡前列素氨丁三醇治疗宫缩乏力性产后出血患者的效果

一次性宫腔压迫球囊联合卡前列素氨丁三醇治疗宫缩乏力性产后出血患者的效果

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目的:观察一次性宫腔压迫球囊联合卡前列素氨丁三醇治疗宫缩乏力性产后出血患者的效果.方法:回顾性分析 2020 年10 月至 2023 年 6 月该院收治的 114 例宫缩乏力性产后出血患者的临床资料,根据治疗方案不同将其分为对照组和观察组各 57 例.对照组予以卡前列素氨丁三醇治疗,观察组在对照组基础上联合一次性宫腔压迫球囊治疗,比较两组临床疗效、产后不同时间段出血量、治疗前后凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)]水平、血清一氧化氮(NO)水平、一氧化氮合酶(NOS)水平和治疗后 3 d内不良反应发生率.结果:观察组治疗总有效率为 96.49%(55/57),高于对照组的 85.96%(49/57),差异有统计学意义(P<0.05);观察组产后 1~2 d和 2~3 d出血量均少于对照组,差异有统计学意义(P<0.05);治疗后,观察组PT、APTT、TT均短于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清NO、NOS水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:一次性宫腔压迫球囊联合卡前列素氨丁三醇治疗宫缩乏力性产后出血患者可提高治疗总有效率,改善凝血功能指标水平,降低产后出血量、NO和NOS水平,效果优于单纯卡前列素氨丁三醇治疗.
Effects of disposable intrauterine compression balloon combined with Carboprost tromethamine in treatment of patients with postpartum hemorrhage due to uterine inertia
Objective:To observe effects of disposable intrauterine compression balloon combined with Carboprost tromethamine in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 114 patients with postpartum hemorrhage due to uterine inertia admitted to this hospital from October 2020 to June 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and observation group,57 cases in each group.The control group was treated with Carboprost tromethamine,while the observation group was treated with disposable intrauterine compression balloon on the basis of that of the control group.The clinical efficacy,the postpartum hemorrhage volumes at different time periods,the coagulation function indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)and fibrinogen(FIB)]levels before and after the treatment,the serum nitric oxide(NO)level,the nitric oxide synthase(NOS)level,and the incidence of adverse reactions within 3 days after the treatment were compared between the two groups.Results:The total effective rate of the observation group was 96.49%(55/57),which was higher than 85.96%(49/57)of the control group,and the difference was statistically significant(P<0.05).The hemorrhage volumes 1-2 d and 2-3 d after delivery in the observation group were less than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PT,APTT and TT in the observation group were shorter than those in the control group,the FIB level was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum NO and NOS in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Disposable intrauterine compression balloon combined with Carboprost tromethamine can improve the total effective rate of treatment,improve the levels of coagulation function indexes,and reduce the volume of postpartum hemorrhage and the serum NO and NOS levels.Moreover,it is superior to single Carboprost tromethamine treatment.

Disposable intrauterine compression balloonCarboprost tromethamineUterine inertiaPostpartum hemorrhageHemorrhage volumeCoagulation functionAdverse reaction

郭靖

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开封市妇产医院产科,河南 开封 475000

一次性宫腔压迫球囊 卡前列素氨丁三醇 宫缩乏力 产后出血 出血量 凝血功能 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(11)
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