Application effects of computer-assisted language training combined with repetitive transcranial magnetic stimulation in patients with aphasia
Objective:To observe application effects of computer-assisted language training combined with repetitive transcranial magnetic stimulation(rTMS)in patients with aphasia.Methods:A prospective study was conducted on 118 patients with aphasia admitted to the hospital from April 2020 to April 2022.According to the random number table method,they were divided into study group and control group,59 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with rTMS,while the study group was treated with computer-assisted language training on the basis of that of the control group.Both groups were treated for 3 months.The clinical efficacy,the serological indexes[central nervous specific protein(S100β),brain-derived neurotrophic factor(BDNF),matrix metalloproteinase(MMP)-2,MMP-9]levels,the language function[Chinese rehabilitation research center standard aphasia examination(CRRCAE)]score,and the cognitive function[mini-mental state examination scale(MMSE)]score were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 89.83%(53/59),which was higher than 74.58%(44/59)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of S100β,MMP-2 and MMP-9 in the study group were lower than those in the control group,the level of BDNF was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the CRRCAE score of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Further,after the treatment,the MMSE score of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:The computer-assisted language training combined with rTMS in the patients with aphasia can improve the total effective rate of treatment,the language function scores and the cognitive function scores,and improve the levels of serological indexes.Moreover,it is superior to single rTMS treatment.
AphasiaTranscranial magnetic stimulationComputer-assisted language trainingLanguage functionCognitive function
NETL
NSTL
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