Effects of compound Danshen dripping pills combined with Metoprolol in treatment of patients with chronic heart failure complicated with paroxysmal atrial fibrillation
Objective:To observe effects of compound Danshen dripping pills combined with Metoprolol in treatment of patients with chronic heart failure(CHF)complicated with paroxysmal atrial fibrillation(PAF).Methods:The clinical data of 150 patients with CHF complicated with PAF admitted to this hospital from January 2021 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,75 cases in each group.The control group was treated with Metoprolol succinate sustained-release tablets orally,while the study group was treated with compound Danshen dripping pills orally on the basis of that of the control group.The clinical efficacy,the clinical symptoms(heart rate,frequency and duration of atrial fibrillation episodes),the myocardial injury markers[creatine kinase isoenzyme(CK-MB),growth differentiation factor 15(GDF-15),N-terminal pro-brain natriuretic peptide(NT-proBNP)]levels,the vascular endothelial function indicators[endothelin-1(ET-1),homocysteine(Hcy)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 92.00%(69/75),which was higher than 80.00%(60/75)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the heart rate of the study group was lower than that of the control group,the frequency of atrial fibrillation episodes was less than that of the control group,the duration of atrial fibrillation episodes was shorter than that of the control group,and the differences were statistically significant(P<0.05).The levels of CK-MB,NT-proBNP,GDF-15,ET-1 and Hcy in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound Danshen dripping pills combined with Metoprolol is effective in the treatment of CHF patients with PAF,which can reduce the atrial fibrillation symptoms,reduce the heart rate,reduce the myocardial injury,and protect the vascular endothelial function.Moreover,it is superior to single Metoprolol treatment.
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