Comparison of effects of Bivalirudin and Heparin on perioperative anticoagulation in patients with ST-segment elevation acute myocardial infarction undergoing PCI
Objective:To compare effects of Bivalirudin and Heparin on perioperative anticoagulation in patients with ST-segment elevation acute myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Methods:A prospective study was conducted on 102 STEMI patients who underwent PCI in this hospital from March 2020 to March 2023.According to the random number table method,they were divided into study group and control group,51 cases in each group.The control group was treated with Heparin sodium injection for anticoagulation during the perioperative period of PCI,while the study group was treated with Bivalirudin for injection.The levels of inflammatory factors[serum interleukin(IL)-4,IL-8,high-sensitivity C-reactive protein(hs-CRP)],serological indexes[growth differentiation factor-15(GDF-15),brain natriuretic peptide(BNP),cardiac troponin I(cTnI)],and the incidence of cardiovascular and cerebrovascular adverse events 6 months after the surgery were compared between the two groups.Results:At discharge,the levels of serum IL-4,IL-8,hs-CRP,GDF-15,BNP and cTnI in the two groups were lower than those before the surgery,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Six months after the surgery,the incidence of cardiovascular and cerebrovascular adverse events in the study group was 3.92%,which was significantly lower than 15.69%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Bivalirudin for perioperative anticoagulation in the STEMI patients undergoing PCI can reduce the levels of serum inflammatory factors,GDF-15,BNP,cTnI and the incidence of cardiovascular and cerebrovascular adverse events.Moreover,it is superior Heparin treatment.
NETL
NSTL
万方数据
