Effects of Zhenwu decoction combined with continuous veno-venous hemodiafiltration in treatment of sepsis patients with acute renal injury
Objective:To observe effects of Zhenwu decoction combined with continuous veno-venous hemodiafiltration(CVVHDF)in treatment of sepsis patients with acute renal injury.Methods:A prospective study was conducted on 82 sepsis patients with acute renal injury admitted to Ruzhou People's Hospital from December 2020 to December 2022.They were divided into control group and observation group according to the random number table method,41 cases in each.The control group was treated with CVVHDF,while the observation group was treated with Zhenwu decoction on the basis of that of the control group.The clinical efficacy,the prognostic indicators(ICU stay time,urine volume recovery time,organ support treatment time)levels,the renal function indicators[serum creatinine(Scr),urea nitrogen(BUN),cystatin C(CysC)]levels before and after the treatment,the acute physiology and chronic health evaluation scoring system Ⅱ(APACHE Ⅱ)score,and the T cell subsets(CD3+,CD4+,CD4+/CD8+)levels were compared between the two groups.Results:The total effective rate of the observation group was 92.68％(38/41),which was higher than 70.73％(29/41)of the control group,and the difference was statistically significant(P<0.05).The ICU stay time,the urine volume recovery time and the organ support treatment time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The levels of Scr,BUN,CysC and APACHE Ⅱ scores in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the levels of CD3+,CD4+and CD4+/CD8+in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Zhenwu decoction combined with CVVHDF can improve the total effective rate of treatment and the levels of T cell subsets,and reduce the levels of prognostic indicators and renal function indicators and the APACHE Ⅱ scores in the sepsis patients with acute kidney injury.Moreover,it is superior to single CVVHDF.
SepsisAcute kidney injuryContinuous veno-venous hemodiafiltrationZhenwu decoctionRenal function
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