Effects of Xuefu Zhuyu capsules combined with low molecular weight heparin calcium injection on anticoagulation after total hip arthroplasty
Objective:To observe effects of Xuefu Zhuyu capsules combined with low molecular weight heparin calcium injection on anticoagulation after total hip arthroplasty.Methods:A prospective study was conducted on 126 patients after total hip arthroplasty admitted to the hospital from May 2021 to May 2023.According to the random number table method,they were divided into observation group and control group,63 cases in each group.The control group was treated with low molecular weight heparin calcium injection for anticoagulation,while the observation group was combined with Xuefu Zhuyu capsules for anticoagulation on the basis of that of the control group.The lower extremity circumference difference,the pain visual analogue scale(VAS)score,the coagulation-fibrinolysis indexes[activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D),fibrinogen(FIB),fibrin degradation product(FDP)]levels,the incidence of lower limb DVT,and the incidence of adverse reactions were compared between the two groups.Results:After 2 weeks of treatment,the circumference differences of thigh and calf in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 1 and 2 weeks of treatment,the VAS scores of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 2 weeks of treatment,the levels of APTT and PT in the two groups were longer than those before the treatment,and those in the observation group were longer than those in the control group;the levels of D-D,FIB and FDP in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).The incidence of lower extremity DVT in the observation group was 0,which was lower than 9.52%in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xuefu Zhuyu capsules combined with low molecular weight heparin calcium injection for anticoagulation in the patients after total hip arthroplasty can reduce the lower limb circumference levels,the VAS scores and the incidence of lower limb DVT,and improve the levels of coagulation-fibrinolysis indexes.Moreover,it is superior to single low molecular weight heparin calcium injection treatment.
Xuefu Zhuyu capsulesLow molecular weight heparin calcium injectionAnticoagulationTotal hip arthroplastyDeep venous thrombosis of lower extremityCoagulation-fibrinolysis
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