Predictive value of combined detection of serum SDC-1,HDAC6 and CC16 levels for poor prognosis in patients with chronic obstructive pulmonary disease
Objective:To investigate predictive value of combined detection of serum multiligand proteoglycan 1(SDC-1),histone deacetylase 6(HDAC6)and Clara cell secretory protein 16(CC16)levels for poor prognosis in patients with chronic obstructive pulmonary disease(COPD).Methods:A cross-sectional study was conducted on 147 patients with COPD admitted to the hospital from November 2020 to November 2023,and they were set as the study group.147 healthy people who underwent physical examination in the hospital during the same period were selected and they were set as the control group.The serum levels of SDC-1,HDAC6 and CC16 were compared between the two groups and among the patients with different severity of COPD and the patients with different prognosis of COPD.The receiver operating characteristic(ROC)curve was used to analyze the value of single and combined detection of serum SDC-1,HDAC6 and CC16 levels at admission in the prediction of poor prognosis of the COPD patients.Results:The levels of serum SDC-1 and HDAC6 in the study group were higher than those in the control group,the level of serum CC16 was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum SDC-1 and HDAC6 in the patients with severe COPD were higher than those in the patients with moderate to severe,moderate and mild COPD,those in the patients with moderate to severe COPD were higher than those in the patients with moderate and mild COPD,and those in the patients with moderate COPD were higher than those in the patients with mild COPD;the serum CC16 level in the patients with severe COPD was lower than that in the patients with moderate to severe,moderate and mild COPD,that in the patients with moderate to severe COPD was lower than that in the patients with moderate and mild COPD,and that in the patients with moderate COPD was lower than that in the patients with mild COPD;and the differences were statistically significant(P<0.05).The levels of serum SDC-1 and HDAC6 at admission in the patients with poor prognosis were higher than those in the patients with good prognosis,the level of serum CC16 was lower than that in the patients with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of combined detection of serum SDC-1,HDAC6 and CC16 levels at admission in the prediction of poor prognosis of the COPD patients was 0.938,which was higher than that of single detection of the three(AUC=0.774,0.771,0.716).Conclusions:The value of combined detection of serum SDC-1,HDAC6 and CC16 levels at admission in the prediction of poor prognosis of the COPD patients is higher than that of single detection of the three.
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