Comparison of effects of Sacubitril/Valsartan and Enalapril in treatment of elderly patients with heart failure with reduced ejection fraction
Objective:To compare effects of Sacubitril/Valsartan and Enalapril in treatment of elderly patients with heart failure with reduced ejection fraction(HFrEF).Methods:A prospective study was conducted on 82 elderly patients with HFrEF admitted to the hospital from January 2020 to December 2022.According to the random number table method,they were divided into observation group and control group,41 cases in each group.On the basis of routine treatment,the control group was treated with Enalapril maleate tablets orally,while the observation group was treated with Sacubitril/Valsartan sodium tablets orally.The clinical efficacy,the levels of ventricular remodeling indexes[left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],myocardial injury indexes[cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)]and inflammatory factors[interferon-γ(IFN-γ),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.56%(40/41),which was higher than 80.49%(33/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the level of LVEF in the observation group was higher than that in the control group,the levels of LVEDD,LVPWT,cTnI,NT-proBNP,cTnI,MMP-9,IFN-γ and IL-6 were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compared with Enalapril,Sacubitril/Valsartan in the treatment of the elderly patients with HFrEF can improve the clinical efficacy,inhibit the ventricular remodeling,reduce the myocardial injury,and reduce the levels of inflammatory factors with similar safety.
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