Effects of Carvedilol combined with Valsartan in treatment of patients with hypertension and ventricular arrhythmia
Objective:To observe effects of Carvedilol combined with Valsartan in treatment of patients with hypertension and ventricular arrhythmia.Methods:A prospective study was conducted on 80 patients with hypertension and ventricular arrhythmia admitted to the hospital from June 2021 to June 2023.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with Valsartan,while the study group was treated with Carvedilol on the basis of that of the control group.The clinical efficacy,the levels of inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)],cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)],vascular endothelial function indexes[endothelin-1(ET-1),homocysteine(Hcy)]and heart rate variability indexes[standard deviation of the average NN intervals(SDANN),root mean square successive differences between successive R-Rintervals(RMSSD),standard deviation of NN intervals(SDNN)]were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 90.00%(36/40),which was higher than 72.50%(29/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PCT,CRP and WBC in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of LVEF in the observation group was higher than that in the control group,the levels of LVESD and LVEDD were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET-1 and Hcy in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Furth,after the treatment,SDANN,RMSSD and SDNN in the observation group were longer than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Carvedilol combined with Valsartan in the treatment of the patients with hypertension and ventricular arrhythmia can improve the total effective rate of treatment,prolong the heart rate variability index level,improve the levels of cardiac function indexes,reduce the levels of inflammatory indexes and vascular endothelial function indexes.Moreover,it is superior to single Valsartan treatment.
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