Effects of Metoprolol tartrate combined with Amiodarone in treatment of patients with acute myocardial infarction complicated with malignant arrhythmia
Objective:To observe effects of Metoprolol tartrate combined with Amiodarone in treatment of patients with acute myocardial infarction(AMI)complicated with malignant arrhythmia.Methods:A prospective study was conducted on 65 patients with AMI complicated with malignant arrhythmia admitted to the hospital from June 2021 to May 2023.According to the random number table method,they were divided into observation group(33 cases)and control group(32 cases).Both groups were given routine treatment.On this basis,the control group was treated with Amiodarone,while the observation group was treated with Metoprolol tartrate on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the levels of myocardial injury markers[creatine kinase isoenzyme(CK-MB),myoglobin(Mb),cardiac troponin I(cTnI)]and cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.94%(31/33),which was higher than 75.00%(24/32)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CK-MB,Mb and cTnI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of LVEDD and LVESD in the observation group were lower than those in the control group,the level of LVEF was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Metoprolol tartrate combined with Amiodarone in the treatment of the AMI patients with malignant arrhythmia can improve the total effective rate of treatment,reduce the levels of myocardial injury markers,and improve the levels of cardiac function indicators.Moreover,it is superior to single Amiodarone treatment.
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