Effects of Labetalol combined with Nifedipine in treatment of patients with preeclampsia
Objective:To observe effects of Labetalol combined with Nifedipine in treatment of patients with preeclampsia.Methods:A prospective study was conducted on 80 patients with preeclampsia admitted to the hospital from June 2021 to June 2023.According to the random number table method,they were divided into control group and observation group,40 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Nifedipine,while the observation group was treated with Labetalol on the basis of that of the control group.Both groups were treated continuously for 1 month.The clinical efficacy,the levels of blood pressure(systolic blood pressure,diastolic blood pressure),the 24 h urine protein quantitative,the coagulation function index[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)],and the fetal umbilical artery blood flow index[ratio of systolic blood pressure to diastolic blood pressure(S/D),pulsatility index(PI),resistance index(RI)],the incidence of adverse pregnancy outcomes,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.50%(39/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure,diastolic blood pressure and 24 h urinary protein in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PT,APTT and TT in the observation group were longer than those in the control group,the level of FIB was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the fetal umbilical artery S/D,PI and RI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).From follow-up to delivery,the incidence of adverse pregnancy outcomes in the observation group was 17.50%(7/40),which was lower than 55.00%(22/40)in the control group,the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Labetalol combined with Nifedipine in the treatment of the patients with preeclampsia can improve the total effective rate of treatment,reduce the blood pressure,24 h urine protein quantification,fetal umbilical artery blood flow index levels and incidence of adverse pregnancy outcomes,and improve the levels of coagulation function indexes.Moreover,it is superior to single Nifedipine treatment.
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