Effects of Zhengan Xifeng decoction combined with Levodopa and Benserazide hydrochloride tablets in treatment of patients with Parkinson's disease of liver and kidney deficiency type
Objective:To observe effects of Zhengan Xifeng decoction combined with Levodopa and Benserazide hydrochloride tablets in treatment of patients with Parkinson's disease of liver and kidney deficiency type.Methods:The clinical data of 65 patients with Parkinson's disease admitted from November 2021 to November 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=32)and observation group(n=33).The control group was treated with Levodopa and Benserazide hydrochloride tablets,while the observation group was treated with Zhengan Xifeng decoction on the basis of that of the control group.The clinical efficacy,the quality of life[unified Parkinson's disease rating scale(UPDRS)]score before and after the treatment,the cytokine indicators[brain-derived neurotrophic factor(BDNF),central nervous system specific protein(S100β),neurotrophic factor-3(NT-3)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 87.88%(29/33),which was higher than 65.62%(21/32)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the UPDRS scores of daily living ability,mental and emotional disorders,and motor signs in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of BDNF and NT-3 in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of S100β in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusions:Zhengan Xifeng decoction combined with Levodopa and Benserazide Hydrazine tablets in the treatment of Parkinson's disease of liver and kidney deficiency type can improve the clinical efficacy,improve the quality of life and the neurological function.Moreover,it is superior to simple Levodopa and Benserazide hydrochloride tablets treatment.
Zhengan Xifeng decoctionLevodopa and Benserazide hydrochloride tabletsParkinson's diseaseLiver and kidney deficiencyCytokineAdverse reaction
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