Comparison of effects of Fasudil and Nimodipine on patients with intracranial wide-necked aneurysm rupture after coil embolization
Objective:To compare effects of Fasudil and Nimodipine on patients with intracranial wide-necked aneurysm rupture after coil embolization.Methods:A prospective study was conducted on 80 patients with ruptured intracranial wide-necked aneurysms admitted to the hospital from January 2021 to March 2023.According to the random number method,they were divided into control group and study group,40 cases in each group.Both groups were treated with stent-assisted coil embolization.On this basis,the control group was treated with Nimodipine injection,while the study group was treated with Fasudil hydrochloride injection.The prognosis[modified Rankin scale(mRS)],the degree of neurological deficit before and after the treatment[National Institutes of Health stroke scale(NIHSS)],the incidence of cerebral vasospasm,and the incidence of adverse reactions were compared between the two groups.Results:The mRS and NIHSS scores of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of cerebral vasospasm in the study group was 0,which was lower than 15.00%(7/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Fasudil used in the patients with intracranial wide-necked aneurysm rupture after coil embolization can effectively reduce the incidence of cerebral vasospasm,reduce the neurological deficits,and improve the prognosis.Moreover,it is superior to Nimodipine treatment.
Intracranial aneurysmsRuptureFasudilNimodipineStent-assisted coil embolizationCerebral vasospasmNeurological function
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