Effects of Moxifloxacin combined with Biapenem in the treatment of patients with severe pneumonia
Objective:To observe effects of Moxifloxacin combined with Biapenem in treatment of patients with severe pneumonia.Methods:A prospective study was conducted on 104 patients with severe pneumonia admitted to the hospital from June 2021 to June 2023.According to the random number table method,they were divided into study group and control group,52 cases in each group.The control group was treated with Biapenem,while the study group was treated with Moxifloxacin on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[interleukin(IL)-1β,IL-18]and respiratory function indexes[oxygenation index(OI),dynamic compliance(Cdyn),respiratory work(WOB)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 94.23%(49/52),which was higher than 76.92%(40/52)in the control group,and the difference was statistically significant(P＜0.05).After the treatment,the levels of IL-1β and IL-18 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After the treatment,the levels of OI and Cdyn in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the WOB of the two groups was lower than that before the treatment,and that in the study group was lower than that in the control group;and the difference was statistically significant(P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P＜0.05).Conclusions:Moxifloxacin combined with Biapenem in the treatment of the patients with severe pneumonia can improve the total effective rate of treatment,improve the levels of respiratory function indicators,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Biapenem treatment.
Severe pneumoniaMoxifloxacinBiapenemInflammatory factorRespiratory functionAdverse reaction
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