Effects of Labetalol combined with Magnesium sulfate in treatment of patients with gestational hypertension
Objective:To observe effects of Labetalol combined with Magnesium sulfate in the treatment of patients with gestational hypertension.Methods:A prospective study was conducted on 90 patients with gestational hypertension admitted to the hospital from May 2021 to May 2022.According to the random number table method,they were divided into observation group and control group,45 cases in each group.The control group was treated with Magnesium sulfate,while the observation group was treated with Labetalol on the basis of that of the control group.The blood pressure level,the vascular endothelial function index[superoxide dismutase(SOD),endothelin-1(ET-1),nitric oxide(NO)]levels,the oxidative stress index[malondialdehyde(MDA),myeloperoxidase(MPO)]levels before and after the treatment,and the incidence of adverse pregnancy outcomes,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of diastolic blood pressure and systolic blood pressure in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After the treatment,the levels of SOD and NO in the observation group were higher than those in the control group,the level of ET-1 was lower than that in the control group,and the differences were statistically significant(P＜0.05).After the treatment,the levels of MDA and MPO in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse pregnancy outcomes in the observation group was 2.22%(1/45),which was lower than 22.22%(10/45)in the control group,and the difference was statistically significant(P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions:Labetalol combined with Magnesium sulfate can reduce the blood pressure levels,improve the vascular endothelial function index levels,reduce the oxidative stress index levels and the incidence of adverse pregnancy outcomes in the patients with gestational hypertension.Moreover,it is superior to single Magnesium sulfate treatment.
NETL
NSTL
万方数据
