Effects of combined Clostridium Butyricum and Bifidobacterium powders,live combined with Ceftizoxime sodium in treatment of children with antibiotic-associated diarrhea
Objective:To observe effects of combined Clostridium Butyricum and Bifidobacterium powders,live combined with Ceftizoxime sodium in treatment of children with antibiotic-associated diarrhea(AAD).Methods:A prospective study was conducted on 74 children with AAD admitted to this hospital from March 2022 to May 2023.According to the random number table method,they were divided into control group and study group,37 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Ceftizoxime sodium,while the study group was treated with combined Clostridium Butyricum and Bifidobacterium powders,live on the basis of that of the control group.Both groups were treated for 3 d.The clinical efficacy,the levels of clinical related indicators(antidiarrheal time,stool character recovery time and hospitalization time),the number of intestinal flora(Bifidobacterium,Lactobacillus,Escherichia coli,Eubacterium)and the levels of inflammatory factors[C-reactive protein(CRP),interleukin(IL)-2,IL-6,tumor necrosis factor-α(TNF-α),procalcitonin(PCT)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 97.30%(36/37),which was higher than 78.38%(29/37)of the control group,and the difference was statistically significant(P＜0.05).The antidiarrheal time,the stool character recovery time and the hospitalization time in the study group were shorter than those in the control group,the differences were statistically significant(P＜0.05).After the treatment,the number of Lactobacillus,Bifidobacterium and Eubacterium in the study group was more than that in the control group,the number of Escherichia coli was less than that in the control group,and the difference was statistically significant(P＜0.05).After the treatment,the levels of TNF-α,CRP,IL-6,PCT and IL-2 in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).However,there were no obvious adverse reactions in the two groups during the treatment.Conclusions:Combined Clostridium Butyricum and Bifidobacterium powders,live combined with Ceftizoxime sodium in the treatment of the children with AAD can improve the total effective rate of treatment,improve the levels of clinical indicators,regulate the number of intestinal flora,and reduce the levels of inflammatory factors.Moreover,it is superior to simple Ceftizoxime sodium treatment.
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