首页|丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果

丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果

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目的:观察丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果.方法:选取 2020 年 10 月至 2023 年 10 月信阳市妇幼保健院神经内科收治的 92 例急性脑梗死患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各 46 例.对照组采用阿替普酶静脉溶栓治疗,研究组在对照组基础上联合注射用丹参多酚酸盐治疗,比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、肢体运动功能量表(FMA)评分、Barthel指数(BI)评分、血清炎性指标[单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α刺激基因-6(TSG-6)、可溶性细胞间黏附分子-1(sICAM-1)]水平、血管内皮功能指标[血清内皮素-1(ET-1)、同型半胱氨酸(Hcy)、一氧化氮(NO)]水平和不良反应发生率.结果:研究组治疗总有效率为89.13%,明显高于对照组的71.74%,差异有统计学意义(P<0.05);治疗后,两组BI、FMA评分和血清NO水平高于治疗前,且研究组高于对照组,两组NIHSS评分和血清TSG-6、sICAM-1、MCP-1、ET-1、Hcy水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死患者可提高治疗总有效率、BI评分和FMA评分,改善血管内皮功能指标水平,以及降低NIHSS评分和炎性指标水平,效果优于单纯阿替普酶静脉溶栓治疗.
Effects of Salvianolic acid combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction
Objective:To observe effects of Salvianolic acid combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 92 patients with acute cerebral infarction admitted Department of Neurology of Xinyang Maternal and Child Health Hospital from October 2020 to October 2023.According to the random number table method,they were divided into study group and control group,46 cases in each group.The control group was treated with intravenous thrombolysis with Alteplase,while the study group was treated with Salvianolic acid for injection on the basis of that of the control group.The clinical efficacy,the National Institutes of Health stroke scale(NIHSS)score,the limb motor function scale(FMA)score,the Barthel index(BI)score,the serum inflammatory indexes[monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α stimulating gene-6(TSG-6),soluble intercellular adhesion molecule-1(sICAM-1)]levels,the vascular endothelial function indexes[serum endothelin-1(ET-1),homocysteine(Hcy),nitric oxide(NO)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 89.13%,which was significantly higher than 71.74%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the BI and FMA scores and the serum NO levels in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the NIHSS scores and the serum levels of TSG-6,sICAM-1,MCP-1,ET-1 and Hcy in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusions:Salvianolic acid combined with Alteplase intravenous thrombolysis in the patients with acute cerebral infarction can improve the total effective rate of treatment,the BI scores and the FMA scores,improve the levels of vascular endothelial function indexes,and reduce the levels of NIHSS score and inflammatory indexes.Moreover,it is superior to simple Alteplase intravenous thrombolysis treatment.

Salvianolic acidAlteplaseAcute cerebral infarctionNeurological deficitVascular endothelial functionInflammatory factor

葛俊伟、李晓楠

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信阳市妇幼保健院神经内科,河南 信阳 464000

河南省军区信阳离职干部休养所老年病科,河南 信阳 464000

丹参多酚酸 阿替普酶 急性脑梗死 神经功能缺损 血管内皮功能 炎性因子

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(14)
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