Effects of modified Guizhi Fuling capsule combined with antibiotics in treatment of patients with chronic pelvic inflammatory disease
Objective:To observe effects of modified Guizhi Fuling capsule combined with antibiotics in treatment of patients with chronic pelvic inflammatory disease.Methods:A prospective study was conducted on 76 patients with chronic pelvic inflammatory disease admitted to the hospital from December 2020 to February 2022.According to the random number table method,they were divided into control group and observation group,38 cases in each group.The control group was treated with conventional antibiotics,while the observation group was treated with Guizhi Fuling capsule on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the pain degree[visual analogue scale(VAS)]score,the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]levels before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 97.37%(37/38),which was higher than 78.95%(30/38)of the control group,and the difference was statistically significant(P＜0.05).After the treatment,the scores of TCM syndromes such as lower abdominal pain or dull pain,lumbosacral pain,tenderness in the attachment area,and abnormal vaginal discharge in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The VAS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P＜0.05).After the treatment,the levels of IL-6,TNF-α and CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The recurrence rate of the observation group was 7.89%(3/38),which was lower than 26.32%(10/38)of the control group,and the difference was statistically significant(P＜0.05).Conclusions:Modified Guizhi Fuling capsule combined with antibiotics in the treatment of the patients with chronic pelvic inflammatory disease can improve the total effective rate of treatment and reduce the TCM syndrome scores,the pain degree scores,the inflammatory factor levels and the recurrence rate.Moreover,it is superior to simple conventional antibiotic treatment.
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