Effects of Tirofiban combined with conventional antiplatelet drugs in treatment of patients with cerebral infarction beyond the thrombolysis time window
Objective:To observe effects of Tirofiban combined with conventional antiplatelet drugs in treatment of patients with cerebral infarction beyond the thrombolysis time window.Methods:A prospective study was conducted on 120 patients with cerebral infarction beyond thrombolysis time window admitted to the hospital from January 2021 to December 2022.According to the random number table method,they were divided into control group and observation group,60 cases in each group.The control group was treated with conventional dual antiplatelet(Aspirin enteric-coated tablets+Clopidogrel hydrogen sulfate tablets),while the observation group was treated with Tirofiban hydrochloride sodium chloride injection on the basis of that of the control group.The clinical efficacy,the levels of neurological deficit degree[National Institutes of Health stroke scale(NIHSS)],the cognitive function[Montreal cognitive assessment(MoCA)],the serum biochemical indexes[Angiopoietin-1(Ang-1),P-selectin,nitric oxide(NO),vascular endothelial growth factor(VEGF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(58/60),which was higher than that of the control group 86.67%(52/60),and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the P-selectin level in the observation group were lower than those in the control group,the MoCA score and the levels of Ang-1,NO and VEGF were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tirofiban combined with conventional dual antiplatelet therapy has a significant effect on the patients with cerebral infarction beyond the thrombolysis time window,which can reduce the vascular endothelial injury and neurological deficits and improve the cognitive function.Moreover,it is superior to simple dual antiplatelet therapy.
TirofibanBeyond the thrombolysis time windowCerebral infarctionDual anti-plateletAspirinClopidogrel
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