Effects of Compound brain peptide ganglioside injection combined with mild hypothermia therapy in treatment of patients with severe craniocerebral injury
Objective:To observe effects of Compound brain peptide ganglioside injection combined with mild hypothermia therapy in treatment of patients with severe craniocerebral injury.Methods:A prospective study was conducted on 80 patients with severe craniocerebral injury admitted to this hospital from January 2020 to December 2022.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with mild hypothermia therapy,while the study group was treated with Compound brain peptide ganglioside injection on the basis of that of the control group.The cognitive status[modified Montreal scale(MoCA),mini-mental state examination(MMSE)]score,the neurological deficit degree[National Institutes of Health stroke scale(NIHSS)]score,the limb function[Fugl-Meyer motor assessment(FMA)]score,the nerve injury related indicators[calcitonin gene-related peptide(CGRP),neuropeptide Y(NPY),glial fibrillary acidic protein(GFAP)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the scores of MoCA and MMSE in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The NIHSS scores of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the FMA scores of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The levels of CGRP in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of NPY and GFAP in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound brain peptide ganglioside combined with mild hypothermia in the treatment of the patients with severe craniocerebral injury can improve the cognitive status and the limb function scores,improve the levels of nerve injury related indicators,and reduce the neurological deficit scores.Moreover,it is superior to simple mild hypothermia treatment.
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