Effects of Ertugliflozin combined with Metformin in treatment of patients with obese type 2 diabetes
Objective:To observe effects of Ertugliflozin combined with Metformin in treatment of patients with obese type 2 diabetes.Methods:The clinical data of 82 patients with obese type 2 diabetes admitted to this hospital from June 2020 to August 2023 were retrospectively analyzed.According to different treatment plans,they were divided into control group and observation group,41 cases in each group.The control group was treated with Metformin hydrochloride tablets,while the observation group was treated with Ertugliflozin tablets on the basis of that of the control group.The clinical efficacy,the levels of blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],the blood lipid indexes[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)],the islet function indexes[fasting insulin(FINS),islet β cell function index(HOMA-β),insulin resistance index(HOMA-IR)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.56%(40/41),which was higher than 80.49%(33/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FPG,HbA1c,2hPG and FINS in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FPG,HbA1c,2hPG,FINS,HOMA-IR,TC,TG and LDL-C in the observation group were lower than those in the control group,the levels of HOMA-β and HDL-C were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ertugliflozin combined with Metformin is effective in the treatment of obese type 2 diabetes,which can reduce the levels of blood glucose indexes,regulate the levels of blood lipid indexes and improve the islet function.Moreover,it is superior to simple Metformin treatment.
ErtugliflozinMetforminObese type 2 diabetesBlood lipidIslet function
万方数据
维普
