Effects of Tofacitinib combined with Methotrexate in treatment of patients with rheumatoid arthritis
Objective:To observe effects of Tofacitinib combined with Methotrexate in treatment of patients with rheumatoid arthritis(RA).Methods:The clinical data of 60 patients with RA admitted to this hospital from May 2020 to June 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,30 cases in each group.The control group was treated with Methotrexate,while the study group was treated with Tofacitinib on the basis of that of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the clinical symptoms(joint swelling,pain,morning stiffness)scores,the bone metabolism indexes[type Ⅰ collagen carboxy-terminal propeptide(PⅠNP),β-collagen degradation product(β-CTX),N-terminal middle segment of osteocalcin(N-MID),osteoprotegerin(OPG)]levels,the inflammatory indexes[interleukin-8(IL-8),clusterin(CLU),C-reactive protein(CRP),chitinase 3-like protein 1(CHI3L1)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(28/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of joint swelling,pain and morning stiffness in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PINP,N-MID and OPG in the study group were higher than those in the control group,the levels of β-CTX,IL-8,CRP,CHI3L1 and CLU were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tofacitinib combined with Methotrexate in the treatment of the RA patients can improve the total effective rate of treatment,improve the levels of bone metabolism indexes and reduce the clinical symptom scores and the inflammatory index levels.Moreover,it is superior to simple Methotrexate treatment.
万方数据
维普
