Application effects of Parecoxib sodium preemptive analgesia combined with postoperative Sufentanil patient-controlled intravenous analgesia in patients undergoing lower limb fracture surgeries
Objective:To observe application effects of Parecoxib sodium preemptive analgesia combined with postoperative Sufentanil patient-controlled intravenous analgesia in patients undergoing lower limb fracture surgeries.Methods:The clinical data of 60 patients with lower limb fracture surgeries admitted to this hospital from July 2022 to May 2023 were retrospectively analyzed.According to different analgesic schemes,they were divided into control group and observation group,30 cases in each group.Both groups underwent general anesthesia.On this basis,The control group was given Sufentanil citrate injection for patient-controlled intravenous analgesia after the surgery,while the observation group was combined with Parecoxib sodium for preemptive analgesia on the basis of that of the control group.The levels of anesthesia related indicators(anesthesia recovery time,extubation time,consciousness recovery time),the postoperative pain degree[visual analogue scale(VAS)]score,the emergence agitation[Riker sedation and agitation(SAS)]score,the stress indexes[cortisol(Cor),norepinephrine(NE)]levels before and after the surgery,and the incidence of adverse reactions were compared between the two groups.Results:There were no significant differences in the anesthesia recovery time,the extubation time and the consciousness recovery time between the two groups(P>0.05).6,12,24 and 48 h after the surgery,the VAS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The SAS score of the observation group in the recovery period was lower than that of the control group,and the difference was statistically significant(P<0.05).24 h after the surgery,the levels of Cor and NE in the two groups were higher than those before the treatment,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Parecoxib sodium preemptive analgesia combined with postoperative Sufentanil patient-controlled intravenous analgesia in the patients undergoing lower limb fracture surgeries can reduce the SAS scores and the stress index levels during the recovery period.Moreover,it is superior to simple postoperative Sufentanil patient-controlled intravenous analgesia.
万方数据
维普
