Effects of Bifidobacterium quadruple viable tablets combined with insulin pump in treatment of patients with gestational diabetes mellitus
Objective:To observe effects of Bifidobacterium quadruple viable tablets combined with insulin pump in treatment of patients with gestational diabetes mellitus.Methods:A prospective study was conducted on 89 patients with gestational diabetes mellitus admitted to Nanyang Longhai hospital from September 2021 to September 2023.According to the random number table method,they were divided into control group(44 cases)and observation group(45 cases).The control group was treated with insulin pump,while the observation group was treated with Bifidobacterium quadruple viable tablets on the basis of the control group.Both groups were treated for 1 month.The levels of blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],islet function indexes[fasting insulin(FINS),islet β cell function index(HOMA-β),insulin sensitivity index(ISI),insulin resistance index(HOMA-IR)],and oxidative stress indexes[total antioxidant capacity(T-AOC),malondialdehyde(MDA),superoxide dismutase(SOD)]before and after the treatment,the incidence of adverse reactions,and the incidence of adverse pregnancy outcomes were compared between the two groups.Results:After the treatment,the levels of HbA1c,2hPG and FPG in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FINS and HOMA-IR in the observation group were lower than those in the control group,the levels of HOMA-β and ISI were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MDA in the observation group was lower than those in the control group,the level of T-AOC and SOD were higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of adverse pregnancy outcomes in the observation group was 11.11%(5/45),which was lower than 29.55%(13/44)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Bifidobacterium quadruple viable tablets combined with insulin pump in the treatment of gestational diabetes mellitus can reduce the levels of blood glucose indexes and the incidence of adverse pregnancy outcomes,and improve the levels of islet function indexes and oxidative stress indexes.Moreover,it is superior to simple insulin pump treatment.
万方数据
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