Effects of Montelukast sodium combined with Salmeterol fluticasone in treatment of children with bronchial asthma
Objective:To observe effects of Montelukast sodium combined with Salmeterol fluticasone in treatment of children with bronchial asthma.Methods:A prospective study was conducted on 86 children with bronchial asthma admitted to the hospital from May 2021 to May 2023.According to the random number table method,they were divided into control group and study group,43 cases in each group.The control group was treated with Salmeterol fluticasone,while the study group was treated with Montelukast sodium on the basis of that of the control group.The total effective rate of treatment,the levels of lung function indexes[forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC),daily sputum excretion],inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)]and arterial blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2)]were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV1 and FEV1/FVC in the study group were higher than those in the control group,the daily sputum volume was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,PCT and WBC in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Furter,after the treatment,the PaCO2 level of the study group was lower than that of the control group,the SaO2 level was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusions:Montelukast sodium combined with Salmeterol fluticasone in the treatment of the children with bronchial asthma can improve the levels of pulmonary function indexes and arterial blood gas analysis indexes,and reduce the levels of inflammatory indexes.Moreover,it is superior to simple Salmeterol fluticasone treatment.
Montelukast sodiumSalmeterol fluticasoneBronchial asthmaChildrenLung functionBlood gas analysis indexInflammatory factor
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