Effects of Xiangdan injection combined with conventional Western medicine in treatment of patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type
Objective:To observe effects of Xiangdan injection combined with conventional Western medicine in treatment of patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type.Methods:A prospective study was conducted on 78 patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type admitted to the hospital from February 2021 to April 2023.According to the random number table method,they were divided into observation group(n=39)and control group(n=39).The control group was treated with conventional Western medicine,while the observation group was treated with Xiangdan injection on the basis of that of the control group.The clinical efficacy,the angina pectoris attack,the levels of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)]and the disease-related indexes[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),vasodilator-stimulated phosphoprotein(VASP),pregnancy-associated plasma protein A(PAPP-A)]levels before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the frequency of angina pectoris in the observation group was lower than that in the control group,the duration was shorter than that in the control group,the dosage of Nitroglycerin was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of LVEDD and LVESD in the observation group were lower than those in the control group,the level of LVEF was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-α and PAPP-A in the observation group were lower than those in the control group,the VASP level was higher than that in the control group,and the differences were statistically significant(P<0.05).During the treatment,no obvious adverse reactions occurred in the two groups.Conclusions:Xiangdan injection combined with conventional Western medicine can improve the total effective rate of treatment,improve the attack of angina pectoris,the levels of cardiac function indexes and the levels of disease related indexes in the patients with angina pectoris of coronary heart disease of qi deficiency and blood stasis type.Moreover,it is superior to conventional Western medicine treatment.
万方数据
维普
