Effects of Bufei Xiaoji decoction combined with AP chemotherapy in treatment of patients with advanced non-small cell lung cancer
Objective:To observe effects of Bufei Xiaoji decoction combined with AP chemotherapy regimen(Pemetrexed+Cisplatin)in treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:A prospective study was conducted on 86 patients with advanced NSCLC admitted to this hospital from September 2020 to September 2023.According to the random number table method,they were divided into study group and control group,43 cases in each group.The control group was treated with AP chemotherapy regimen,while the study group was treated with Bufei Xiaoji decoction on the basis of that of the control group.The clinical efficacy,the levels of tumor markers[cytokeratin 21-1 fragment(CYFRA21-1),carcinoembryonic antigen(CEA)],the scores of quality of life[Functional Assessment of Cancer Therapy-Lung cancer(FACT-L)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The disease control rate of the study group was 95.35%(41/43),which was higher than 79.01%(34/43)of the control group.After the treatment,the levels of CYFRA21-1 and CEA in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the FACT-L scores of the two groups were higher than those before the treatment,those of the study group were higher than the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bufei Xiaoji decoction combined with AP chemotherapy regimen for the patients with advanced NSCLC can improve the disease control rate and the quality of life,reduce the levels of tumor markers,and has good safety.Moreover,it is superior to simple AP chemotherapy regimen.
万方数据
维普
