Effects of Yinxie capsules combined with Acitretin capsules in treatment of patients with psoriasis vulgaris
Objective:To observe effects of Yinxie capsules combined with Acitretin capsules in treatment of patients with psoriasis vulgaris.Methods:A prospective study was conducted on 200 patients with psoriasis vulgaris admitted to this hospital from July 2022 to July 2023.According to the random number table method,they were divided into control group(n=100)and observation group(n=100).The control group was treated with Acitretin capsules,while the observation group was treated with Yinxie capsules on the basis of that of the control group.The clinical efficacy,the itching degree[four-item itching questionnaire(FIIQ)]score,the quality of life[dermatology life quality index(DLQI)]score,the T cell subsets[regulatory T cells(Treg),helper T cells 1(Th1),helper T cells 17(Th17)]levels,the inflammatory factors[interleukin-6(IL-6),interleukin-23(IL-23),C-reactive protein(CRP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.00%(93/100),which was higher than 82.00%(82/100)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the FIIQ and DLQI scores of the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Treg in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of Th1 and Th17 in the two groups were lower than those before the treatment,and those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,IL-23 and CRP in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Yinxie capsules combined with Acitretin capsules in the treatment of the patients with psoriasis vulgaris can improve the total effective rate of treatment,improve the levels of T cell subsets,and reduce the FIIQ scores,the DLQI scores and the inflammatory factor levels.Moreover,it is superior to simple Acitretin capsules treatment.
Psoriasis vulgarisYinxie capsulesAcitretin capsulesItchingInflammatory factorQuality of lifeT cell subset
万方数据
维普
