Analysis of distribution and drug resistance of pathogenic bacteria in secretions of patients with poor healing of incision infection after orthopedic surgery
Objective:To analyze distribution and drug resistance of pathogenic bacteria in secretions of patients with poor healing of incision infection after orthopedic surgery.Methods:A cross-sectional study was conducted on 284 patients with poor healing of incision infection after orthopedic surgery in this hospital from October 2021 to October 2023.The distribution of pathogenic bacteria in the secretions of these patients was statistically analyzed.The drug resistance of main Gram-negative and positive strains to different antibiotics was analyzed.Results:A total of 337 strains of pathogenic bacteria were detected in the 284 patients,including 176 strains of Gram-positive bacteria(52.23%),mainly Staphylococcus aureus(102 strains),and 161 strains(47.77%)of Gram-negative bacteria,mainly Pseudomonas aeruginosa(43 strains).Staphylococcus aureus had the highest resistance to Penicillin(98.04%),followed by Ampicillin(92.16%)and Erythromycin(47.06%);it had lower resistance to Amikacin,Compound sulfanilamide,Ciprofloxacin,Quinupristin/Dalfopristin,Linezolid,Rifampicin,and Tobramycin(all<10%),but had no resistance to Nitrofurantoin,Trimethoprim,Mupirocin,Teicoplanin,and Vancomycin.Coagulase negative staphylococci had the highest resistance to Penicillin(91.07%),higher resistance to Ampicillin,Amoxicillin/Clavulanic acid,Oxacillin,Erythromycin,and Cefoxitin(all>50.00%),lower resistance to Amikacin,Nitrofurantoin,Linezolid,Rifampicin,Mupirocin,and Tobramycin(all<10%),and no resistance to Dalfopristin,Teicoplanin,and Vancomycin.Pseudomonas aeruginosa had the highest resistance to Chloramphenicol and Cefazolin(both 86.05%),followed by Ampicillin and Ampicillin/Sulbactam(both 83.71%),Amoxicillin/Clavulanic acid,and Compound sulfonamide(both 76.74%),and had no resistance to Amikacin,Meropenem,Piperacillin,Piperacillin/tazobactam,Cefepime,and Ceftazidime.Acinetobacter baumannii had the highest resistance to Amoxicillin/Clavulanic acid and Ampicillin(both 100.00%),followed by Cefazolin(84.62%),Ampicillin(84.62%),and Chloramphenicol(65.38%);but it was not resistant to Amikacin and Compound sulfanilamide.Escherichia coli had the highest resistance to Ampicillin,Tetracycline,and Cefazolin(all 100.00%),followed by Piperacillin(76.32%),Compound sulfanilamide(73.68%),Cefotaxime(73.68%),Moxifloxacin(63.16%),Levofloxacin(63.16%),and Gentamicin(60.53%);and it had no resistance to Amikacin,Amoxicillin/Clavulanic acid,Meropenem,Piperacillin/Tazobactam,and Imipenem.Enterobacter cloacae had the highest resistance to Amoxicillin/Clavulanic acid,Ampicillin,Ampicillin/Sulbactam,and Cefazolin(all 100.00%),and was not resistant to Meropenem,Piperacillin/Tazobactam,or Imipenem.Conclusions:The pathogenic bacteria in the secretions of the patients with poor healing of incision infection after orthopedic surgery are mainly Staphylococcus aureus and Pseudomonas aeruginosa,and they have of resistance to various commonly used antibiotics.
OrthopaedicsPostoperativeInfectionPoor healing of incisionSecretionPathogenic bacteriaDrug resistance
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