Effects of Gabapentin combined with microvascular decompression in treatment of patients with primary trigeminal neuralgia
Objective:To observe effects of Gabapentin combined with microvascular decompression in treatment of patients with primary trigeminal neuralgia.Methods:A prospective study was conducted on 82 patients with primary trigeminal neuralgia admitted to the hospital from February 2022 to February 2023.According to the random number table method,they were divided into study group and control group,41 cases in each group.The control group was treated with microvascular decompression,while the study group was treated with Gabapentin on the basis of that of the control group.The clinical efficacy,the levels of neuroendocrine factor indexes[calcitonin gene-related peptide(CGRP),neuron specific enolase(NSE)]and neurotransmitter indexes[β-endorphin(β-EP),5-hydroxytryptamine(5-HT)]before and after the treatment,and the incidence of complications/adverse reactions and recurrence rate were compared between the two groups.Results:The total effective rate of the study group was 95.12%(39/41),which was higher than 78.05%(32/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CGRP and NSE in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of β-EP and 5-HT in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications/adverse reactions between the two groups(P>0.05).The recurrence rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusions:Gabapentin combined with microvascular decompression in the treatment of the patients with primary trigeminal neuralgia can improve the total effective rate of treatment and the levels of neurotransmitter indexes,and reduce the levels of neuroendocrine factors and the recurrence rate.Moreover,it is superior to simple microvascular decompression treatment.
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