Effects of Acetylcysteine combined with Budesonide aerosol inhalation in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease
Objective:To observe effects of Acetylcysteine combined with Budesonide aerosol inhalation in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The clinical data of 86 patients with AECOPD admitted to this hospital from January 2022 to May 2023 were retrospectively analyzed.According to different treatment methods,they were divided into observation group(n=43)and control group(n=43).The control group was treated with Budesonide aerosol inhalation,while the observation group was treated with Acetylcysteine aerosol inhalation on the basis of that of the control group.The clinical efficacy,the lung function indexes[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)]levels,the inflammatory indexes[interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),eosinophil(EOS)]levels before and after the treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of the observation group was 93.02%(40/43),which was higher than 76.74%(33/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FVC,FEV1 and PEF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of EOS,TNF-α and IL-4 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Acetylcysteine combined with Budesonide aerosol inhalation in the treatment of the AECOPD patients can improve the total effective rate of treatment and the levels of lung function indexes,and reduce the levels of inflammatory indicators.Moreover,it is superior to simple Budesonide aerosol inhalation treatment.
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