Effects of laparoscopic gastrorrhaphy in treatment of patients with acute gastric perforation
Objective:To observe effects of laparoscopic gastrorrhaphy in treatment of patients with acute gastric perforation.Methods:The clinical data of 102 patients with acute gastric perforation admitted to this hospital from August 2021 to August 2023 were retrospectively analyzed.According to different surgical methods,they were divided into observation group(n=51)and control group(n=51).The observation group was treated with laparoscopic gastrorrhaphy,while the control group was treated with open gastrorrhaphy.The perioperative index levels,the gastrointestinal hormone indexes[gastrin(GAS),pepsinogen(PG)Ⅰ,PGⅡ,motilin(MTL)]levels,the inflammatory stress factors[interleukin-8(IL-8),norepinephrine(NE),prostaglandin E2(PGE2),C-reactive protein(CRP)]levels,the pain degree[visual analogue scale(VAS)]score before and after surgery,and the incidence of complications 1 week after the surgery were compared between the two groups.Results:The operation time,the hospitalization time and the first exhaust time of the observation group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).Three days after the surgery,the levels of GAS,PGⅠ,MTL and PGⅡ in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Three days after the surgery,the levels of IL-8,NE,CRP and PGE2 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).One and 3 days after the surgery,the VAS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Laparoscopic gastrorrhaphy for the patients with acute gastric perforation can improve the levels of gastrointestinal hormones and reduce the levels of perioperative indexes,the inflammatory stress factors and the pain scores.Moreover,it is superior to open gastrorrhaphy.
NETL
NSTL
万方数据
