Effects of Carboprost methylate suppositories combined with Carboprost tromethamine in treatment of postpartum hemorrhage in patients with placenta previa
Objective:To observe effects of Carboprost methylate suppositories combined with Carboprost tromethamine in treatment of postpartum hemorrhage in patients with placenta previa.Methods:A prospective study was conducted on 80 postpartum hemorrhage patients with of placenta previa admitted to the hospital from April 2021 to April 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Carboprost tromethamine,while the study group was treated with Carboprost methylate suppositories on the basis of that of the control group.The hemostatic effect,the perinatal index levels,the coagulation function indexes[prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of hemostasis in the study group was 92.50%(37/40),which was higher than 75.00%(30/40)in the control group,the difference was statistically significant(P<0.05).The amount of bleeding 2 and 24 h after delivery in the study group were less than those in the control group,the duration of lochia and the bleeding reduction time were shorter than those in the control group,the duration of uterine contraction were longer than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the FIB levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of APTT,TT and PT in the two groups were shorter than those before the treatment,and those in the study group were shorter than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carboprost methylate suppositories combined with Carboprost tromethamine in the treatment of the postpartum hemorrhage patients with placenta previa can improve the total effective rate of hemostasis and improve the levels of perinatal indexes and coagulation function indicators.Moreover,it is superior to simple Carboprost tromethamine treatment.
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