Effects of Xuezhikang capsules combined with Atorvastatin calcium in treatment of patients with hypertension complicated with coronary heart disease
Objective:To observe effects of Xuezhikang capsules combined with Atorvastatin calcium in treatment of patients with hypertension complicated with coronary heart disease.Methods:A prospective study was conducted on 85 patients with hypertension and coronary heart disease admitted to this hospital from March 2020 to March 2023.According to the random number table method,they were divided into control group(42 cases)and study group(43 cases).The control group was treated with Atorvastatin calcium,while the study group was treated with Xuezhikang capsules on the basis of that of the control group.The clinical efficacy and the levels of lipid metabolism indexes[low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triacylglycerol(TG)],vascular endothelial function indexes[endothelin-1(ET-1),nitric oxide(NO),homocysteine(Hcy)]and blood pressure were compared between the two groups before and after the treatment.Results:The total effective rate of the study group was 95.35%(41/43),which was higher than 78.57%(33/42)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TG and LDL-C in the study group were lower than those in the control group,the level of HDL-C was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET-1 and Hcy in the study group were lower than those in the control group,the level of NO was higher than that in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the levels of systolic blood pressure and diastolic blood pressure in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Xuezhikang capsules combined with Atorvastatin calcium in the treatment of the patients with hypertension and coronary heart disease can improve the total effective rate of treatment,improve the levels of lipid metabolism indexes and vascular endothelial function indexes,and reduce the levels of blood pressure.Moreover,it is superior to simple Atorvastatin calcium treatment.
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